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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
30/10/2019 |
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Data da última atualização: |
30/10/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MARCHESI, J. A. P.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; PANDOLFI, J. R. C.; MARCIANO, C. M. M.; ZANELLA, R.; SETTLES, M. L.; COUTINHO, L. L.; LEDUR, M. C. |
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Afiliação: |
JORGE AUGUSTO PETROLI MARCHESI, USP; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; JOSE RODRIGO CLAUDIO PANDOLFI, CNPSA; CAROLINE M. MARINHO MARCIANO, UDESC/Chapecó; RICARDO ZANELLA, UPF; MATTHEW LEE SETTLES, University of California; LUIZ LEHMMAN COUTINHO, USP; MONICA CORREA LEDUR, CNPSA. |
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Título: |
Whole transcriptome analysis of the pectoralis major muscle reveals molecular mechanisms involved with white striping in broiler chickens. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Poultry Science, v. 98, n. 2, p. 590-601, 2019. |
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DOI: |
10.3382/ps/pey429 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: White striping (WS) is one of the most common myopathies identified in broiler chickens leading to substantial production losses, where the incidence reaches 12% in commercial chickens. It occurs primarily in heavier chickens being a modification of the breast muscle characterized by the presence of pale parallel streaks in the same orientation of the muscle fibers. Since the WS etiology remains unclear, we aimed to identify the biological and genetic mechanisms involved in its occurrence through the whole transcriptome analysis of WS in affected and unaffected chicken breast muscles. A total of 11,177 genes were expressed in the pectoralis major muscle. Out of those, 1,441genes were differentially expressed (FDR ? 0.01) between the two analyzed groups, being, respectively, 772 genes upregulated and 669 downregulated in the WS affected group. A total of 36 significantly overrepresented GO terms related to WS myopathy were enriched, and the most relevant biological processes were activation of immune system, angiogenesis, hypoxia, cell death, and striated muscle contraction. The unbalance of those biological processes may trigger the occurrence of the WS phenotype in broilers. The possible lack of capillary blood supply homogeneously in the muscle triggers the hypoxia, following the activation of glycolysis, calcium signaling and apoptosis related genes facilitating the tissue damage and WS incidence. |
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Palavras-Chave: |
Breast myopathy; Muscle disorder; RNA-Seq. |
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Thesagro: |
Frango de Corte; Genética Animal; Genética Molecular. |
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Thesaurus Nal: |
Animal genetics; Broiler chickens; Sequence analysis. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02484naa a2200349 a 4500
001 2113642
005 2019-10-30
008 2019 bl uuuu u00u1 u #d
024 7 $a10.3382/ps/pey429$2DOI
100 1 $aMARCHESI, J. A. P.
245 $aWhole transcriptome analysis of the pectoralis major muscle reveals molecular mechanisms involved with white striping in broiler chickens.$h[electronic resource]
260 $c2019
520 $aAbstract: White striping (WS) is one of the most common myopathies identified in broiler chickens leading to substantial production losses, where the incidence reaches 12% in commercial chickens. It occurs primarily in heavier chickens being a modification of the breast muscle characterized by the presence of pale parallel streaks in the same orientation of the muscle fibers. Since the WS etiology remains unclear, we aimed to identify the biological and genetic mechanisms involved in its occurrence through the whole transcriptome analysis of WS in affected and unaffected chicken breast muscles. A total of 11,177 genes were expressed in the pectoralis major muscle. Out of those, 1,441genes were differentially expressed (FDR ? 0.01) between the two analyzed groups, being, respectively, 772 genes upregulated and 669 downregulated in the WS affected group. A total of 36 significantly overrepresented GO terms related to WS myopathy were enriched, and the most relevant biological processes were activation of immune system, angiogenesis, hypoxia, cell death, and striated muscle contraction. The unbalance of those biological processes may trigger the occurrence of the WS phenotype in broilers. The possible lack of capillary blood supply homogeneously in the muscle triggers the hypoxia, following the activation of glycolysis, calcium signaling and apoptosis related genes facilitating the tissue damage and WS incidence.
650 $aAnimal genetics
650 $aBroiler chickens
650 $aSequence analysis
650 $aFrango de Corte
650 $aGenética Animal
650 $aGenética Molecular
653 $aBreast myopathy
653 $aMuscle disorder
653 $aRNA-Seq
700 1 $aIBELLI, A. M. G.
700 1 $aPEIXOTO, J. de O.
700 1 $aCANTAO, M. E.
700 1 $aPANDOLFI, J. R. C.
700 1 $aMARCIANO, C. M. M.
700 1 $aZANELLA, R.
700 1 $aSETTLES, M. L.
700 1 $aCOUTINHO, L. L.
700 1 $aLEDUR, M. C.
773 $tPoultry Science$gv. 98, n. 2, p. 590-601, 2019.
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Embrapa Suínos e Aves (CNPSA) |
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| Registros recuperados : 4 | |
| 1. |  | MARCHESI, J. A. P.; IBELLI, A. M. G.; CANTAO, M. E.; ZANELLA, R.; SETTLES, M. L.; PEIXOTO, J. de O.; COUTINHO, L. L.; LEDUR, M. C. Whole transcriptome analysis of pectoralis major muscle reveals differences in calcium signaling pathway between white striping affected and unaffected broilers. In: CONGRESSO BRASILEIRO DE GENÉTICA, 61., 2015, Águas de Lindóia. Resumos... Ribeirão Preto: Sociedade Brasileira de Genética, 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 2. | | PEIXOTO, J. de O.; SAVOLDI, I. R.; IBELLI, A. M. G.; CANTAO, M. E.; JAENISCH, F. R. F.; GIACHETTO, P. F.; SETTLES, M. L.; ZANELLA, R.; MARCHESI, J. A. P.; PANDOLFI, J. R. C.; COUTINHO, L. L.; LEDUR, M. C. Proximal femoral head transcriptome reveals novel candidate genes related to epiphysiolysis in broiler chickens. BMC Genomics, v. 20, p. 1-17, 2019. Na publicação: José Rodrigo Pandolfi. Article number: 1031.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Suínos e Aves. |
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| 3. | | PEIXOTO, J. de O.; IBELLI, A. M. G.; CANTAO, M. E.; ZANELLA, R.; JAENISCH, F. R. F.; GIACHETTO, P. F.; SETTLES, M. L.; PANDOLFI, J. R. C.; COUTINHO, L. L.; LEDUR, M. C. Expressão gênica diferencial envolvida com condronecrose bacteriana com osteomielite em frangos de corte com 35 dias de idade. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 52., 2015, Belo Horizonte. Zootecnia: otimizando recursos e potencialidades: anais. Brasília, DF: Sociedade Brasileira de Zootecnia, 2015.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Suínos e Aves. |
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| 4. | | MARCHESI, J. A. P.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; PANDOLFI, J. R. C.; MARCIANO, C. M. M.; ZANELLA, R.; SETTLES, M. L.; COUTINHO, L. L.; LEDUR, M. C. Whole transcriptome analysis of the pectoralis major muscle reveals molecular mechanisms involved with white striping in broiler chickens. Poultry Science, v. 98, n. 2, p. 590-601, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| Registros recuperados : 4 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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